Adriana Elena Bulboacă 1,Alina S. Porfire 2,Lucia R. Tefas 2,Paul Mihai Boarescu 1,* ,Sorana D. Bolboacă 3,* OrcID,Ioana C. Stănescu 4,Angelo Corneliu Bulboacă 4 andGabriela Dogaru 5

Abstract: Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test the effect of intraperitoneal (i.p.) administration of liposomal curcumin (lCC) as pre-treatment in streptozotocin(STZ)-induced DM in rats on oxidative stress, liver, and pancreatic functional parameters. Forty-two Wistar-Bratislava rats were randomly divided into six groups (seven animals/group): control (no diabetes), control-STZ (STZ-induced DM —60 mg/100g body weight a single dose intraperitoneal administration, and no CC pre-treatment), two groups with DM and CC pre-treatment (1mg/100g bw—STZ + CC1, 2 mg/100g bw—STZ + CC2), and two groups with DM and lCC pre-treatment (1 mg/100g bw—STZ + lCC1, 2 mg/100g bw—STZ + lCC1). Intraperitoneal administration of Curcumin in diabetic rats showed a significant reduction of nitric oxide, malondialdehyde, total oxidative stress, and catalase for both evaluated formulations (CC and lCC) compared to control group (p < 0.005), with higher efficacy of lCC formulation compared to CC solution (p < 0.002, excepting catalase for STZ + CC2vs. STZ + lCC1when p = 0.0845). The CC and lCC showed hepatoprotective and hypoglycemic effects, a decrease in oxidative stress and improvement in anti-oxidative capacity status against STZ-induced DM in rats (p < 0.002). The lCC also proved better efficacy on MMP-2, and -9 plasma levels as compared to CC (p < 0.003, excepting STZ + CC2 vs. STZ + lCC1 comparison with p = 0.0553). The lCC demonstrated significantly better efficacy as compared to curcumin solution on all serum levels of the investigated markers, sustaining its possible use as adjuvant therapy in DM.

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Were investigated the relationship between gender, cardiovascular risk factors and inflammation in metabolicsyndrome (MetS) patients. 100 consecutive patients (75 women), 73 with MetS, mean age 57.52±9.77years, were examined. Adhesion molecules (sICAM1, sVCAM1) were measured in the stored serum samplescollected using the ELISA method. The classification of MetS was based on IDF guidelines. The study wascarried out at the Department of Cardiology, Clinical Rehabilitation Hospital, Cluj-Napoca, Romania. MetSpatients presented lower sICAM1 values (225.01±86.75 ng/mL vs 234.22±82.23 ng/mL, p=NS), but highersVCAM1 values (605.34±298.69 ng/mL vs 552.29±233.77 ng/mL, p=NS). Differences between patientswith vs without metabolic syndrome were found only in men for sICAM1 (194.73±37.92 ng/mL vs 282±27.15ng/mL, p<0.001). Considering the HOMA index, a significant difference for sICAM1 was found in men(patients within the upper quartile vs the lower quartile, p=0.002), but also between women and menwithin the upper quartile of HOMA (for sICAM1 p=0.038). No significant differences were found for sVCAM1.In the case of males, sICAM1 was an independent predictor of metabolic syndrome, with a very goodcapacity to identify metabolic syndrome (AUROC=0.987, p=0.0001, Se=89.47%, Sp=100%). In conclusion,just in men, sICAM1 seems to have an excellent capacity to differentiate between MetS+ and MetS- patients,to predict MetS development.

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Universitatea de Medicină și Farmacie „Iuliu Hațieganu” Cluj - Napoca

Proiect / studiu

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